Assay Detail
Functional
CHEMBL3369508
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Antiproliferative activity against human Bel7402 cells assessed as inhibition of cell viability after 48 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Bel-7402 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 1-hydroxyl-3-aminoalkoxy xanthone derivatives as potent anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.59 | 4.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3331591 | — | — | 1 | 4.88 |
| CHEMBL3331590 | — | — | 1 | 4.83 |
| CHEMBL3331593 | — | — | 1 | 4.75 |
| CHEMBL3329243 | — | — | 1 | 4.74 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.70 |
| CHEMBL3331595 | — | — | 1 | 4.70 |
| CHEMBL3331594 | — | — | 1 | 4.69 |
| CHEMBL3331592 | — | — | 1 | 4.68 |
| CHEMBL3331602 | — | — | 1 | 4.62 |
| CHEMBL3331596 | — | — | 1 | 4.26 |
| CHEMBL3331587 | — | — | 1 | 4.17 |
| CHEMBL3331588 | — | — | 1 | 4.11 |
| CHEMBL3331606 | — | — | 1 | - |
| CHEMBL3331605 | — | — | 1 | - |
| CHEMBL3331604 | — | — | 1 | - |
| CHEMBL3331603 | — | — | 1 | - |
| CHEMBL3331601 | — | — | 1 | - |
| CHEMBL3331600 | — | — | 1 | - |
| CHEMBL3331599 | — | — | 1 | - |
| CHEMBL3331598 | — | — | 1 | - |
| CHEMBL3331597 | — | — | 1 | - |
| CHEMBL3331589 | — | — | 1 | - |
| CHEMBL479041 | — | — | 1 | - |
| CHEMBL3331586 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3331591 | — | IC50 | = | 13030.0 | nM | 4.88 |
| CHEMBL3331590 | — | IC50 | = | 14610.0 | nM | 4.83 |
| CHEMBL3331593 | — | IC50 | = | 17940.0 | nM | 4.75 |
| CHEMBL3329243 | — | IC50 | = | 18160.0 | nM | 4.74 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 19840.0 | nM | 4.70 |
| CHEMBL3331595 | — | IC50 | = | 20070.0 | nM | 4.70 |
| CHEMBL3331594 | — | IC50 | = | 20320.0 | nM | 4.69 |
| CHEMBL3331592 | — | IC50 | = | 20830.0 | nM | 4.68 |
| CHEMBL3331602 | — | IC50 | = | 23890.0 | nM | 4.62 |
| CHEMBL3331596 | — | IC50 | = | 54430.0 | nM | 4.26 |
| CHEMBL3331587 | — | IC50 | = | 67900.0 | nM | 4.17 |
| CHEMBL3331588 | — | IC50 | = | 77200.0 | nM | 4.11 |
| CHEMBL3331606 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3331605 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3331604 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3331603 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3331601 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3331600 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3331599 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3331598 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3331597 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3331589 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL479041 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3331586 | — | IC50 | > | 100000.0 | nM | - |