Assay Detail

CHEMBL3369836

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against Influenza A virus A/New York/18/2009 infected in MDCK cells assessed as cell protection after 3 days by cytopathic effect assay

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Influenza A virus (A/New York/18/2009(H1N1))
Cell Type	MDCK
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.

Clark MP, Ledeboer MW, Davies I, Byrn RA, Jones SM, Perola E, Tsai A, Jacobs M, Nti-Addae K, Bandarage UK, Boyd MJ, Bethiel RS, Court JJ, Deng H, Duffy JP, Dorsch WA, Farmer LJ, Gao H, Gu W, Jackson K, Jacobs DH, Kennedy JM, Ledford B, Liang J, Maltais F, Murcko M, Wang T, Wannamaker MW, Bennett HB, Leeman JR, McNeil C, Taylor WP, Memmott C, Jiang M, Rijnbrand R, Bral C, Germann U, Nezami A, Zhang Y, Salituro FG, Bennani YL, Charifson PS.
J Med Chem (2014) 57 : 6668 -6678
PubMed 25019388 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	3	8.02	9.23

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3318007	PIMODIVIR	3.0	1	9.23
CHEMBL1229	OSELTAMIVIR	4.0	1	6.80
CHEMBL660	AMANTADINE	4.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3318007	PIMODIVIR	EC50	=	0.59	nM	9.23
CHEMBL1229	OSELTAMIVIR	EC50	=	160.0	nM	6.80
CHEMBL660	AMANTADINE	EC50	>	10000.0	nM	-