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Assay Detail

CHEMBL3369988

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant carboxy-terminal His-tagged LDHB by UV endpoint assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

L-lactate dehydrogenase B chain (CHEMBL4940)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Dragovich PS, Fauber BP, Boggs J, Chen J, Corson LB, Ding CZ, Eigenbrot C, Ge H, Giannetti AM, Hunsaker T, Labadie S, Li C, Liu Y, Liu Y, Ma S, Malek S, Peterson D, Pitts KE, Purkey HE, Robarge K, Salphati L, Sideris S, Ultsch M, VanderPorten E, Wang J, Wei B, Xu Q, Yen I, Yue Q, Zhang H, Zhang X, Zhou A.
Bioorg Med Chem Lett (2014) 24 : 3764 -3771
PubMed 25037916 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.10 6.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3318485 1 6.07
CHEMBL3318473 1 5.89
CHEMBL3318475 1 5.72
CHEMBL3318482 1 5.70
CHEMBL3318483 1 5.55
CHEMBL3318471 1 5.47
CHEMBL3318481 1 5.31
CHEMBL3318470 1 5.28
CHEMBL3318478 1 5.18
CHEMBL3318468 1 5.16
CHEMBL3318477 1 5.13
CHEMBL3318484 1 5.11
CHEMBL3318423 1 4.96
CHEMBL3318412 1 4.91
CHEMBL3318465 1 4.89
CHEMBL3318474 1 4.82
CHEMBL3318415 1 4.72
CHEMBL3318469 1 4.62
CHEMBL3318466 1 4.57
CHEMBL15976 OXAMATE 1 4.47
CHEMBL3318467 1 4.43
CHEMBL3318472 1 4.30
CHEMBL3318479 1 -
CHEMBL3318480 1 -
CHEMBL3318476 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3318485 IC50 = 860.0 nM 6.07
CHEMBL3318473 IC50 = 1300.0 nM 5.89
CHEMBL3318475 IC50 = 1900.0 nM 5.72
CHEMBL3318482 IC50 = 2000.0 nM 5.70
CHEMBL3318483 IC50 = 2800.0 nM 5.55
CHEMBL3318471 IC50 = 3400.0 nM 5.47
CHEMBL3318481 IC50 = 4900.0 nM 5.31
CHEMBL3318470 IC50 = 5300.0 nM 5.28
CHEMBL3318478 IC50 = 6600.0 nM 5.18
CHEMBL3318468 IC50 = 6900.0 nM 5.16
CHEMBL3318477 IC50 = 7400.0 nM 5.13
CHEMBL3318484 IC50 = 7800.0 nM 5.11
CHEMBL3318423 IC50 = 11000.0 nM 4.96
CHEMBL3318412 IC50 = 12300.0 nM 4.91
CHEMBL3318465 IC50 = 13000.0 nM 4.89
CHEMBL3318474 IC50 = 15000.0 nM 4.82
CHEMBL3318415 IC50 = 19000.0 nM 4.72
CHEMBL3318469 IC50 = 24000.0 nM 4.62
CHEMBL3318466 IC50 = 27000.0 nM 4.57
CHEMBL15976 OXAMATE IC50 = 33800.0 nM 4.47
CHEMBL3318467 IC50 = 37000.0 nM 4.43
CHEMBL3318472 IC50 = 50000.0 nM 4.30
CHEMBL3318479 IC50 > 10000.0 nM -
CHEMBL3318480 IC50 > 10000.0 nM -
CHEMBL3318476 IC50 > 10000.0 nM -