Assay Detail
Functional
CHEMBL3370211
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Inhibition of LPS-induced NO production in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment by Griess reaction
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Oleanolic acid analogs as NO, TNF-α and IL-1β inhibitors: synthesis, biological evaluation and docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.70 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3322658 | — | — | 1 | 5.58 |
| CHEMBL3322657 | — | — | 1 | 5.32 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.96 |
| CHEMBL486822 | ACETYL OLEANOLIC ACID | — | 1 | 4.86 |
| CHEMBL3322656 | — | — | 1 | 4.78 |
| CHEMBL555056 | — | — | 1 | 4.73 |
| CHEMBL3322661 | — | — | 1 | 4.65 |
| CHEMBL3322655 | — | — | 1 | 4.64 |
| CHEMBL3322660 | — | — | 1 | 4.63 |
| CHEMBL3322659 | — | — | 1 | 4.62 |
| CHEMBL3322662 | — | — | 1 | 4.59 |
| CHEMBL1631518 | — | — | 1 | 4.50 |
| CHEMBL470029 | OLEANONIC ACID | — | 1 | 4.42 |
| CHEMBL1797142 | — | — | 1 | 4.41 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 4.38 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3322658 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL3322657 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL140 | CURCUMIN | IC50 | = | 11020.0 | nM | 4.96 |
| CHEMBL486822 | ACETYL OLEANOLIC ACID | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL3322656 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL555056 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL3322661 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL3322655 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL3322660 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL3322659 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL3322662 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL1631518 | — | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL470029 | OLEANONIC ACID | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL1797142 | — | IC50 | = | 39200.0 | nM | 4.41 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 41700.0 | nM | 4.38 |
| CHEMBL7890 | L-NAME | IC50 | = | 69210.0 | nM | 4.16 |