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Assay Detail

CHEMBL3370248

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant rat FAAH preincubated for 3 hrs
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fatty-acid amide hydrolase 1 (CHEMBL3229)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Discovery libraries targeting the major enzyme classes: the serine hydrolases.
Otrubova K, Srinivasan V, Boger DL.
Bioorg Med Chem Lett (2014) 24 : 3807 -3813
PubMed 25037918 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 7.14 9.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3318613 1 9.80
CHEMBL3318617 1 9.72
CHEMBL3318611 1 8.00
CHEMBL3318608 1 7.92
CHEMBL3318620 1 7.38
CHEMBL3318593 1 7.26
CHEMBL3318602 1 7.12
CHEMBL3318590 1 7.10
CHEMBL3318612 1 7.00
CHEMBL3318609 1 6.77
CHEMBL3318600 1 6.75
CHEMBL3318623 1 6.68
CHEMBL3318601 1 6.60
CHEMBL3318618 1 6.54
CHEMBL3318591 1 6.47
CHEMBL3318619 1 6.26
CHEMBL3318621 1 6.15
CHEMBL3318588 1 6.12
CHEMBL3318592 1 6.07
CHEMBL3318622 1 -
CHEMBL3318589 1 -
CHEMBL3318624 1 -
CHEMBL3318625 1 -
CHEMBL3318626 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3318613 Ki = 0.16 nM 9.80
CHEMBL3318617 Ki = 0.19 nM 9.72
CHEMBL3318611 Ki = 10.0 nM 8.00
CHEMBL3318608 Ki = 12.0 nM 7.92
CHEMBL3318620 Ki = 42.0 nM 7.38
CHEMBL3318593 Ki = 55.0 nM 7.26
CHEMBL3318602 Ki = 75.0 nM 7.12
CHEMBL3318590 Ki = 80.0 nM 7.10
CHEMBL3318612 Ki = 100.0 nM 7.00
CHEMBL3318609 Ki = 170.0 nM 6.77
CHEMBL3318600 Ki = 180.0 nM 6.75
CHEMBL3318623 Ki = 210.0 nM 6.68
CHEMBL3318601 Ki = 250.0 nM 6.60
CHEMBL3318618 Ki = 290.0 nM 6.54
CHEMBL3318591 Ki = 340.0 nM 6.47
CHEMBL3318619 Ki = 550.0 nM 6.26
CHEMBL3318621 Ki = 710.0 nM 6.15
CHEMBL3318588 Ki = 750.0 nM 6.12
CHEMBL3318592 Ki = 850.0 nM 6.07
CHEMBL3318622 Ki > 5000.0 nM -
CHEMBL3318589 Ki > 1000.0 nM -
CHEMBL3318624 Ki > 5000.0 nM -
CHEMBL3318625 Ki > 5000.0 nM -
CHEMBL3318626 Ki > 5000.0 nM -