Assay Detail
Binding
CHEMBL3370358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK2/cyclin A (unknown origin) by HTRF kinase assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.10 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330230 | — | — | 1 | 6.61 |
| CHEMBL3330236 | — | — | 1 | 6.59 |
| CHEMBL3330148 | — | — | 1 | 6.48 |
| CHEMBL3330232 | — | — | 1 | 6.41 |
| CHEMBL3330132 | — | — | 1 | 6.07 |
| CHEMBL3330133 | — | — | 1 | 6.07 |
| CHEMBL3330136 | — | — | 1 | 5.79 |
| CHEMBL3330229 | — | — | 1 | 5.50 |
| CHEMBL3330233 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330230 | — | IC50 | = | 246.2 | nM | 6.61 |
| CHEMBL3330236 | — | IC50 | = | 255.99 | nM | 6.59 |
| CHEMBL3330148 | — | IC50 | = | 334.33 | nM | 6.48 |
| CHEMBL3330232 | — | IC50 | = | 393.33 | nM | 6.41 |
| CHEMBL3330132 | — | IC50 | = | 848.82 | nM | 6.07 |
| CHEMBL3330133 | — | IC50 | = | 851.83 | nM | 6.07 |
| CHEMBL3330136 | — | IC50 | = | 1630.44 | nM | 5.79 |
| CHEMBL3330229 | — | IC50 | = | 3187.14 | nM | 5.50 |
| CHEMBL3330233 | — | IC50 | = | 4304.83 | nM | 5.37 |