Assay Detail
Binding
CHEMBL3370373
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Inhibition of GST-fused full length human TTK compound pre-incubated for 15 mins prior ATP addition by MBP-based assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.02 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047943 | — | — | 1 | 8.74 |
| CHEMBL2380586 | — | — | 1 | 8.00 |
| CHEMBL2140523 | — | — | 1 | 7.46 |
| CHEMBL3330411 | — | — | 1 | 6.43 |
| CHEMBL3330239 | — | — | 1 | 5.75 |
| CHEMBL1725279 | SP-600125 | — | 1 | 5.60 |
| CHEMBL3330238 | — | — | 1 | 5.58 |
| CHEMBL3330412 | — | — | 1 | 5.30 |
| CHEMBL3330413 | — | — | 1 | 4.92 |
| CHEMBL315708 | — | — | 1 | 4.92 |
| CHEMBL3330241 | — | — | 1 | 4.77 |
| CHEMBL3330240 | — | — | 1 | 4.75 |
| CHEMBL3330242 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047943 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2380586 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2140523 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3330411 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3330239 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1725279 | SP-600125 | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3330238 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3330412 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3330413 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL315708 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3330241 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3330240 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3330242 | — | IC50 | > | 50000.0 | nM | - |