Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3370374

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of SUMO-tagged human TTK (1-275 residues) compound pre-incubated for 15 mins prior ATP addition by MBP-based assay
ChEMBL ↗
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Dual specificity protein kinase TTK (CHEMBL3983) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.
Laufer R, Ng G, Liu Y, Patel NK, Edwards LG, Lang Y, Li SW, Feher M, Awrey DE, Leung G, Beletskaya I, Plotnikova O, Mason JM, Hodgson R, Wei X, Mao G, Luo X, Huang P, Green E, Kiarash R, Lin DC, Harris-Brandts M, Ban F, Nadeem V, Mak TW, Pan GJ, Qiu W, Chirgadze NY, Pauls HW.
Bioorg Med Chem (2014) 22 : 4968 -4997
PubMed 25043312 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 56 6.92 8.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3330410 — — 1 8.54
CHEMBL3330260 — — 1 8.46
CHEMBL3330409 — — 1 8.44
CHEMBL3330282 — — 1 8.40
CHEMBL3330407 — — 1 8.05
CHEMBL3330408 — — 1 8.00
CHEMBL3330405 — — 1 7.96
CHEMBL3329232 — — 1 7.92
CHEMBL3330404 — — 1 7.85
CHEMBL3330406 — — 1 7.82
CHEMBL3330281 — — 1 7.80
CHEMBL3330256 — — 1 7.80
CHEMBL3330274 — — 1 7.77
CHEMBL3330272 — — 1 7.75
CHEMBL3330279 — — 1 7.62
CHEMBL3330273 — — 1 7.60
CHEMBL3330401 — — 1 7.58
CHEMBL3330402 — — 1 7.58
CHEMBL3330403 — — 1 7.52
CHEMBL3330265 — — 1 7.48
CHEMBL3330278 — — 1 7.46
CHEMBL3330255 — — 1 7.41
CHEMBL3330280 — — 1 7.34
CHEMBL3330285 — — 1 7.33
CHEMBL3330283 — — 1 7.28
CHEMBL3330276 — — 1 7.24
CHEMBL3330284 — — 1 7.21
CHEMBL3330275 — — 1 7.10
CHEMBL3330270 — — 1 7.05
CHEMBL3330264 — — 1 7.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3330410 — IC50 = 2.9 nM 8.54
CHEMBL3330260 — IC50 = 3.5 nM 8.46
CHEMBL3330409 — IC50 = 3.6 nM 8.44
CHEMBL3330282 — IC50 = 4.0 nM 8.40
CHEMBL3330407 — IC50 = 8.9 nM 8.05
CHEMBL3330408 — IC50 = 10.0 nM 8.00
CHEMBL3330405 — IC50 = 11.0 nM 7.96
CHEMBL3329232 — IC50 = 12.0 nM 7.92
CHEMBL3330404 — IC50 = 14.0 nM 7.85
CHEMBL3330406 — IC50 = 15.0 nM 7.82
CHEMBL3330281 — IC50 = 16.0 nM 7.80
CHEMBL3330256 — IC50 = 16.0 nM 7.80
CHEMBL3330274 — IC50 = 17.0 nM 7.77
CHEMBL3330272 — IC50 = 18.0 nM 7.75
CHEMBL3330279 — IC50 = 24.0 nM 7.62
CHEMBL3330273 — IC50 = 25.0 nM 7.60
CHEMBL3330401 — IC50 = 26.0 nM 7.58
CHEMBL3330402 — IC50 = 26.0 nM 7.58
CHEMBL3330403 — IC50 = 30.0 nM 7.52
CHEMBL3330265 — IC50 = 33.0 nM 7.48
CHEMBL3330278 — IC50 = 35.0 nM 7.46
CHEMBL3330255 — IC50 = 39.0 nM 7.41
CHEMBL3330280 — IC50 = 46.0 nM 7.34
CHEMBL3330285 — IC50 = 47.0 nM 7.33
CHEMBL3330283 — IC50 = 53.0 nM 7.28
CHEMBL3330276 — IC50 = 58.0 nM 7.24
CHEMBL3330284 — IC50 = 61.0 nM 7.21
CHEMBL3330275 — IC50 = 80.0 nM 7.10
CHEMBL3330270 — IC50 = 90.0 nM 7.05
CHEMBL3330264 — IC50 = 90.0 nM 7.05
CHEMBL3330266 — IC50 = 250.0 nM 6.60
CHEMBL3330250 — IC50 = 280.0 nM 6.55
CHEMBL3330277 — IC50 = 310.0 nM 6.51
CHEMBL3330258 — IC50 = 330.0 nM 6.48
CHEMBL3330257 — IC50 = 340.0 nM 6.47
CHEMBL3330271 — IC50 = 340.0 nM 6.47
CHEMBL3330254 — IC50 = 380.0 nM 6.42
CHEMBL3330259 — IC50 = 390.0 nM 6.41
CHEMBL3330267 — IC50 = 550.0 nM 6.26
CHEMBL3330253 — IC50 = 580.0 nM 6.24
CHEMBL3330247 — IC50 = 600.0 nM 6.22
CHEMBL3330248 — IC50 = 640.0 nM 6.19
CHEMBL3330262 — IC50 = 710.0 nM 6.15
CHEMBL3330269 — IC50 = 980.0 nM 6.01
CHEMBL3330243 — IC50 = 1400.0 nM 5.85
CHEMBL3330238 — IC50 = 1600.0 nM 5.80
CHEMBL3330239 — IC50 = 1900.0 nM 5.72
CHEMBL3330246 — IC50 = 2300.0 nM 5.64
CHEMBL3330263 — IC50 = 2600.0 nM 5.58
CHEMBL3330251 — IC50 = 4300.0 nM 5.37