Assay Detail
Functional
CHEMBL3370546
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Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma plus LPS-induced NO production
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic and anti-inflammatory prenylated benzoylphloroglucinols and xanthones from the twigs of Garcinia esculenta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.84 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1215429 | GARCIMULTIFLORONE E | — | 1 | 5.96 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 5.41 |
| CHEMBL521005 | HYPERXANTHONE E | — | 1 | 5.40 |
| CHEMBL3314605 | — | — | 1 | 5.19 |
| CHEMBL3314596 | — | — | 1 | 4.89 |
| CHEMBL454261 | GUTTIFERONE F | — | 1 | 4.85 |
| CHEMBL3314606 | — | — | 1 | 4.80 |
| CHEMBL3314603 | — | — | 1 | 4.77 |
| CHEMBL458934 | CAMBOGIN | — | 1 | 4.72 |
| CHEMBL3314598 | — | — | 1 | 4.72 |
| CHEMBL506229 | — | — | 1 | 4.67 |
| CHEMBL1077025 | GARCINIALIPTONE B | — | 1 | 4.67 |
| CHEMBL3314597 | — | — | 1 | 4.60 |
| CHEMBL3314599 | — | — | 1 | 4.54 |
| CHEMBL3314595 | — | — | 1 | 4.41 |
| CHEMBL3314604 | — | — | 1 | 4.38 |
| CHEMBL187265 | — | — | 1 | 4.37 |
| CHEMBL260553 | — | — | 1 | - |
| CHEMBL3314602 | — | — | 1 | - |
| CHEMBL482997 | TOXYLOXANTHONE B | — | 1 | - |
| CHEMBL3314601 | — | — | 1 | - |
| CHEMBL3314600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1215429 | GARCIMULTIFLORONE E | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL521005 | HYPERXANTHONE E | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3314605 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3314596 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL454261 | GUTTIFERONE F | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL3314606 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL3314603 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL458934 | CAMBOGIN | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL3314598 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL506229 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL1077025 | GARCINIALIPTONE B | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL3314597 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL3314599 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL3314595 | — | IC50 | = | 39100.0 | nM | 4.41 |
| CHEMBL3314604 | — | IC50 | = | 41900.0 | nM | 4.38 |
| CHEMBL187265 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL260553 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3314602 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL482997 | TOXYLOXANTHONE B | IC50 | > | 50000.0 | nM | - |
| CHEMBL3314601 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3314600 | — | IC50 | > | 50000.0 | nM | - |