Assay Detail
Binding
CHEMBL3370547
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine spleen cathepsin B using Z-Arg-Arg-AMC as substrate after 30 mins by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Spleen |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Lower homologues of ahpatinin, aspartic protease inhibitors, from a marine Streptomyces sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.72 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3314610 | — | — | 1 | 5.00 |
| CHEMBL3314607 | — | — | 1 | 4.82 |
| CHEMBL301728 | ACETYLPEPSTATIN | — | 1 | 4.77 |
| CHEMBL3314608 | — | — | 1 | 4.60 |
| CHEMBL3314609 | — | — | 1 | 4.58 |
| CHEMBL3314611 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3314610 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3314607 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL301728 | ACETYLPEPSTATIN | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3314608 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3314609 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3314611 | — | IC50 | = | 29000.0 | nM | 4.54 |