Assay Detail
Functional
CHEMBL3370645
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Antiproliferative activity against human MKN45 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.43 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3325999 | — | — | 1 | 7.04 |
| CHEMBL3325998 | — | — | 1 | 6.97 |
| CHEMBL3325993 | — | — | 1 | 6.73 |
| CHEMBL3325995 | — | — | 1 | 6.33 |
| CHEMBL3325994 | — | — | 1 | 6.31 |
| CHEMBL3325992 | — | — | 1 | 6.31 |
| CHEMBL3326000 | — | — | 1 | 6.31 |
| CHEMBL3325996 | — | — | 1 | 6.25 |
| CHEMBL3325997 | — | — | 1 | 6.14 |
| CHEMBL3326001 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3325999 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3325998 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL3325993 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL3325995 | — | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL3325994 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL3325992 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL3326000 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL3325996 | — | IC50 | = | 563.0 | nM | 6.25 |
| CHEMBL3325997 | — | IC50 | = | 726.0 | nM | 6.14 |
| CHEMBL3326001 | — | IC50 | = | 1394.0 | nM | 5.86 |