Assay Detail
Functional
CHEMBL3370647
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Antiproliferative activity against human KB-S15 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB-S15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.78 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 7.75 |
| CHEMBL3325999 | — | — | 1 | 7.11 |
| CHEMBL3325998 | — | — | 1 | 7.02 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.56 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 17.6 | nM | 7.75 |
| CHEMBL3325999 | — | IC50 | = | 77.3 | nM | 7.11 |
| CHEMBL3325998 | — | IC50 | = | 95.4 | nM | 7.02 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 273.0 | nM | 6.56 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 3500.0 | nM | 5.46 |