Assay Detail
Functional
CHEMBL3370648
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Antiproliferative activity against human KB-7d cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB-7d |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.08 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.92 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.10 |
| CHEMBL3325999 | — | — | 1 | 7.15 |
| CHEMBL3325998 | — | — | 1 | 6.94 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL3325999 | — | IC50 | = | 71.1 | nM | 7.15 |
| CHEMBL3325998 | — | IC50 | = | 115.4 | nM | 6.94 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 54000.0 | nM | 4.27 |