Assay Detail
Binding
CHEMBL3370677
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Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of acylurea isosteres of 2-acylaminothiadiazole in the azaxanthene series of glucocorticoid receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 8.40 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3315064 | — | — | 1 | 9.15 |
| CHEMBL3315070 | — | — | 1 | 9.15 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.92 |
| CHEMBL3315066 | — | — | 1 | 8.92 |
| CHEMBL3315063 | — | — | 1 | 8.82 |
| CHEMBL3315049 | — | — | 1 | 8.80 |
| CHEMBL3315062 | — | — | 1 | 8.80 |
| CHEMBL1911270 | — | — | 1 | 8.72 |
| CHEMBL3315065 | — | — | 1 | 8.72 |
| CHEMBL3315067 | — | — | 1 | 8.70 |
| CHEMBL3315061 | — | — | 1 | 8.68 |
| CHEMBL3315051 | — | — | 1 | 8.60 |
| CHEMBL3315069 | — | — | 1 | 8.40 |
| CHEMBL3315058 | — | — | 1 | 8.24 |
| CHEMBL3315052 | — | — | 1 | 8.23 |
| CHEMBL3315057 | — | — | 1 | 8.16 |
| CHEMBL3315068 | — | — | 1 | 8.14 |
| CHEMBL3315060 | — | — | 1 | 8.13 |
| CHEMBL3315054 | — | — | 1 | 8.07 |
| CHEMBL3315059 | — | — | 1 | 8.06 |
| CHEMBL3315055 | — | — | 1 | 8.06 |
| CHEMBL3315053 | — | — | 1 | 7.89 |
| CHEMBL3315050 | — | — | 1 | 7.16 |
| CHEMBL3315056 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3315064 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL3315070 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL384467 | DEXAMETHASONE | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL3315066 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL3315063 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL3315049 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL3315062 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL1911270 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL3315065 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL3315067 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL3315061 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL3315051 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL3315069 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3315058 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL3315052 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL3315057 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL3315068 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL3315060 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL3315054 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL3315059 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL3315055 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL3315053 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL3315050 | — | Ki | = | 69.4 | nM | 7.16 |
| CHEMBL3315056 | — | Ki | = | 110.5 | nM | 6.96 |