Assay Detail
Binding
CHEMBL3371271
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Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometry
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Raji |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.89 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3319587 | — | — | 1 | 8.92 |
| CHEMBL3319585 | — | — | 1 | 8.85 |
| CHEMBL3319478 | — | — | 1 | 8.70 |
| CHEMBL3319586 | — | — | 1 | 8.68 |
| CHEMBL3319482 | — | — | 1 | 8.60 |
| CHEMBL3319578 | — | — | 1 | 8.52 |
| CHEMBL3319584 | — | — | 1 | 8.52 |
| CHEMBL3319479 | — | — | 1 | 8.51 |
| CHEMBL3319588 | — | — | 1 | 8.48 |
| CHEMBL3319484 | — | — | 1 | 8.30 |
| CHEMBL3319580 | — | — | 1 | 8.30 |
| CHEMBL3237875 | — | — | 1 | 8.24 |
| CHEMBL3319481 | — | — | 1 | 8.18 |
| CHEMBL3319483 | — | — | 1 | 8.08 |
| CHEMBL3319579 | — | — | 1 | 7.96 |
| CHEMBL3319582 | — | — | 1 | 7.89 |
| CHEMBL3319583 | — | — | 1 | 7.85 |
| CHEMBL3319581 | — | — | 1 | 7.50 |
| CHEMBL3319577 | — | — | 1 | 7.44 |
| CHEMBL3319591 | — | — | 1 | 7.28 |
| CHEMBL3319480 | — | — | 1 | 6.61 |
| CHEMBL3319589 | — | — | 1 | 6.41 |
| CHEMBL3319592 | — | — | 1 | 6.20 |
| CHEMBL3319590 | — | — | 1 | 5.24 |
| CHEMBL3319477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3319587 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3319585 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3319478 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3319586 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3319482 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3319578 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3319584 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3319479 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL3319588 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3319484 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3319580 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3237875 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3319481 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL3319483 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL3319579 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3319582 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3319583 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3319581 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3319577 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3319591 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3319480 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL3319589 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL3319592 | — | IC50 | = | 632.0 | nM | 6.20 |
| CHEMBL3319590 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3319477 | — | IC50 | > | 50000.0 | nM | - |