Assay Detail
Binding
CHEMBL3371283
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Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.91 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3319604 | — | — | 1 | 6.89 |
| CHEMBL3319593 | — | — | 1 | 6.85 |
| CHEMBL3237875 | — | — | 1 | 6.47 |
| CHEMBL3319481 | — | — | 1 | 6.43 |
| CHEMBL3319482 | — | — | 1 | 5.46 |
| CHEMBL3319581 | — | — | 1 | 5.21 |
| CHEMBL3319577 | — | — | 1 | 5.14 |
| CHEMBL3319483 | — | — | 1 | 4.80 |
| CHEMBL3319579 | — | — | 1 | - |
| CHEMBL3319591 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3319604 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3319593 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3237875 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3319481 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3319482 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3319581 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3319577 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3319483 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3319579 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3319591 | — | IC50 | > | 100000.0 | nM | - |