Assay Detail
Binding
CHEMBL3371692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of purified human GST-tagged PTP-1B using p-nitrophenylphosphate as substrate by spectrophotometry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.92 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3343064 | — | — | 1 | 5.28 |
| CHEMBL3343062 | — | — | 1 | 5.21 |
| CHEMBL3343063 | — | — | 1 | 5.07 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 5.02 |
| CHEMBL400074 | ERYTHRODIOL | — | 1 | 5.02 |
| CHEMBL3126477 | — | — | 1 | 4.79 |
| CHEMBL3343061 | — | — | 1 | 4.75 |
| CHEMBL486822 | ACETYL OLEANOLIC ACID | — | 1 | 4.67 |
| CHEMBL3343065 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3343064 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3343062 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3343063 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL400074 | ERYTHRODIOL | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL3126477 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL3343061 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL486822 | ACETYL OLEANOLIC ACID | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL3343065 | — | IC50 | = | 36500.0 | nM | 4.44 |