Assay Detail

CHEMBL3371862

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ADMET

Reduction in peripheral lymphocyte count in orally dosed dog measured after 24 hrs

ChEMBL ↗

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Target

Canis familiaris (CHEMBL373) ↗

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Canis familiaris (CHEMBL373) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Canis familiaris

CHEMBL373

Anchored from Assay target.

Protein identity Canis familiaris

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Canis lupus familiaris
Confidence	1 — Organism
Curated By	Autocuration

Target

Canis familiaris (CHEMBL373) ↗

Type	ORGANISM
Organism	Canis lupus familiaris

Publication

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.

Buzard DJ, Kim SH, Lopez L, Kawasaki A, Zhu X, Moody J, Thoresen L, Calderon I, Ullman B, Han S, Lehmann J, Gharbaoui T, Sengupta D, Calvano L, Montalban AG, Ma YA, Sage C, Gao Y, Semple G, Edwards J, Barden J, Morgan M, Chen W, Usmani K, Chen C, Sadeque A, Christopher RJ, Thatte J, Fu L, Solomon M, Mills D, Whelan K, Al-Shamma H, Gatlin J, Le M, Gaidarov I, Anthony T, Unett DJ, Blackburn A, Rueter J, Stirn S, Behan DP, Jones RM.
ACS Med Chem Lett (2014) 5 : 1313 -1317
PubMed 25516790 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.24	7.24

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3358920	ETRASIMOD	4.0	1	7.24

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3358920	ETRASIMOD	IC50	=	58.0	nM	7.24