Assay Detail
Binding
CHEMBL3371979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human androgen receptor expressed in mouse C2C12 cells by androgen-specific response element-driven luciferase reporter gene assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | C2C12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3-alkoxy-pyrrolo[1,2-b]pyrazolines as selective androgen receptor modulators with ideal physicochemical properties for transdermal administration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 8.69 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27769 | STANOLONE | 2.0 | 1 | 9.89 |
| CHEMBL3326461 | — | — | 1 | 9.80 |
| CHEMBL3326466 | — | — | 1 | 9.52 |
| CHEMBL3326458 | — | — | 1 | 9.40 |
| CHEMBL3326454 | — | — | 1 | 9.30 |
| CHEMBL3326457 | — | — | 1 | 9.03 |
| CHEMBL3326455 | — | — | 1 | 9.00 |
| CHEMBL3326464 | — | — | 1 | 8.85 |
| CHEMBL3326460 | — | — | 1 | 8.82 |
| CHEMBL3326456 | — | — | 1 | 8.35 |
| CHEMBL3326459 | — | — | 1 | 8.15 |
| CHEMBL3326462 | — | — | 1 | 8.01 |
| CHEMBL3326465 | — | — | 1 | 7.58 |
| CHEMBL3326453 | — | — | 1 | 6.01 |
| CHEMBL3326463 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27769 | STANOLONE | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL3326461 | — | EC50 | = | 0.16 | nM | 9.80 |
| CHEMBL3326466 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3326458 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3326454 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3326457 | — | EC50 | = | 0.93 | nM | 9.03 |
| CHEMBL3326455 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3326464 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3326460 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3326456 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3326459 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL3326462 | — | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL3326465 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3326453 | — | EC50 | = | 978.0 | nM | 6.01 |
| CHEMBL3326463 | — | EC50 | - | — | - |