Assay Detail
Binding
CHEMBL3372265
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Inhibition of JNK3alpha1 (unknown origin) after 1 hr by homogeneous time-resolved fluorescence assay
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.81 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355175 | — | — | 1 | 7.68 |
| CHEMBL3355177 | — | — | 1 | 7.64 |
| CHEMBL3355176 | — | — | 1 | 7.64 |
| CHEMBL3355184 | — | — | 1 | 7.54 |
| CHEMBL3352845 | — | — | 1 | 7.47 |
| CHEMBL3355183 | — | — | 1 | 7.47 |
| CHEMBL3355146 | — | — | 1 | 7.42 |
| CHEMBL3355167 | — | — | 1 | 7.21 |
| CHEMBL3355158 | — | — | 1 | 7.15 |
| CHEMBL3355156 | — | — | 1 | 7.10 |
| CHEMBL3355165 | — | — | 1 | 7.01 |
| CHEMBL3355180 | — | — | 1 | 7.00 |
| CHEMBL3355174 | — | — | 1 | 6.94 |
| CHEMBL3355145 | — | — | 1 | 6.94 |
| CHEMBL3355172 | — | — | 1 | 6.94 |
| CHEMBL3355160 | — | — | 1 | 6.93 |
| CHEMBL3355166 | — | — | 1 | 6.89 |
| CHEMBL3355169 | — | — | 1 | 6.88 |
| CHEMBL3355179 | — | — | 1 | 6.86 |
| CHEMBL3355150 | — | — | 1 | 6.86 |
| CHEMBL3355162 | — | — | 1 | 6.85 |
| CHEMBL3355161 | — | — | 1 | 6.85 |
| CHEMBL3355151 | — | — | 1 | 6.79 |
| CHEMBL3355171 | — | — | 1 | 6.79 |
| CHEMBL3355182 | — | — | 1 | 6.77 |
| CHEMBL3355181 | — | — | 1 | 6.69 |
| CHEMBL3355170 | — | — | 1 | 6.69 |
| CHEMBL3355159 | — | — | 1 | 6.64 |
| CHEMBL3355168 | — | — | 1 | 6.51 |
| CHEMBL3355149 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355175 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3355177 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3355176 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3355184 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3352845 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3355183 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3355146 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL3355167 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3355158 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3355156 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3355165 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3355180 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3355174 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL3355145 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL3355172 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL3355160 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL3355166 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3355169 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL3355179 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL3355150 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL3355162 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL3355161 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL3355151 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL3355171 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL3355182 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL3355181 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL3355170 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL3355159 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3355168 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL3355149 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL3355173 | — | IC50 | = | 594.0 | nM | 6.23 |
| CHEMBL3355147 | — | IC50 | = | 596.0 | nM | 6.22 |
| CHEMBL3355148 | — | IC50 | = | 1829.0 | nM | 5.74 |
| CHEMBL3355153 | — | IC50 | = | 3063.0 | nM | 5.51 |
| CHEMBL3355157 | — | IC50 | = | 4588.0 | nM | 5.34 |
| CHEMBL3355164 | — | IC50 | = | 5184.0 | nM | 5.29 |
| CHEMBL3355178 | — | IC50 | < | 1.0 | nM | - |