Assay Detail
Binding
CHEMBL3372282
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JNK3 in human SH-SY5Y cells assessed as reduction in c-Jun phosphorylation by Western blot assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.80 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355165 | — | — | 1 | 6.06 |
| CHEMBL3355168 | — | — | 1 | 6.04 |
| CHEMBL3355177 | — | — | 1 | 5.84 |
| CHEMBL3355181 | — | — | 1 | 5.72 |
| CHEMBL3355166 | — | — | 1 | 5.63 |
| CHEMBL3355174 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355165 | — | IC50 | = | 866.0 | nM | 6.06 |
| CHEMBL3355168 | — | IC50 | = | 905.0 | nM | 6.04 |
| CHEMBL3355177 | — | IC50 | = | 1436.0 | nM | 5.84 |
| CHEMBL3355181 | — | IC50 | = | 1895.0 | nM | 5.72 |
| CHEMBL3355166 | — | IC50 | = | 2331.0 | nM | 5.63 |
| CHEMBL3355174 | — | IC50 | = | 3250.0 | nM | 5.49 |