Assay Detail
Functional
CHEMBL3372502
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Inhibition of TGF-beta1-induced total collagen accumulation in rat NRK-49F cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | NRK-49F |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4-oxoquinoline-3-carboxamides derivatives as potent anti-fibrosis agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.55 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3358817 | — | — | 1 | 5.70 |
| CHEMBL3352881 | — | — | 1 | 5.64 |
| CHEMBL3358828 | — | — | 1 | 5.60 |
| CHEMBL2010601 | IVACAFTOR | 4.0 | 1 | 5.40 |
| CHEMBL3358819 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3358817 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3352881 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3358828 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2010601 | IVACAFTOR | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3358819 | — | IC50 | = | 4100.0 | nM | 5.39 |