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Target Snapshot

CHEMBL614203 Target Snapshot

NRK-49F · CELL-LINE · Rattus norvegicus

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192Compounds
16Assays
3Approved Drugs
79.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NRK-49F as ChEMBL target CHEMBL614203. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NRK-49F
CELL-LINE · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL614203
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NRK-49F still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNRK-49F
Target TypeCELL-LINE
OrganismRattus norvegicus
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNRK-49F
UniProt AccessionN/A

NRK-49F

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NRK-49F.

Review nameNRK-49F
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

3
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC5079.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL502835 5.96 IC50 1100.0 Approved
CHEMBL3358817 5.7 IC50 2000.0 Preclinical
CHEMBL3352881 5.64 IC50 2300.0 Preclinical
CHEMBL3358828 5.6 IC50 2500.0 Preclinical
CHEMBL4448190 5.43 IC50 3710.0 Preclinical
CHEMBL2010601 5.4 IC50 4000.0 Approved
CHEMBL4518931 5.4 IC50 3960.0 Preclinical
CHEMBL3358819 5.39 IC50 4100.0 Preclinical
CHEMBL4565941 5.37 IC50 4310.0 Preclinical
CHEMBL4587647 5.36 IC50 4350.0 Preclinical
Distribution

pChEMBL Value Distribution

15
5.0
5
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

16
Total Assays
40
Tested Compounds
3
Assay Types
Functional — 11 assays, 40 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 40 4.9
ADME — 3 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 12 4.6
Toxicity — 2 assays, 11 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 11 4.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine