Compound Detail
CHEMBL4448190
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Basic Information
| ChEMBL ID | CHEMBL4448190 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RVNYCDMKBSWGCK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
410.4
MW (Da)
2.86
ALogP
7
HBA
1
HBD
90.2
PSA (Ų)
0.63
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NRK-49F CHEMBL614203 | IC50 | 5.43 | 5.43 | 3710.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NRK-49F | IC50 | = | 3710.0 | nM | 5.43 | Inhibition of TGF-beta-induced collagen accumulation in rat NRK-49F cells incuba... | 31699535 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31699535 | 10.1016/j.ejmech.2019.111790 | NRK-49F | 4 |
| 31699535 | 10.1016/j.ejmech.2019.111790 | NIH3T3 | 1 |
Data from ChEMBL 36 via Core Engine