Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3372544

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of tubulin (unknown origin) polymerization incubated 15 mins prior to GTP addition by spectrophotometry
ChEMBL ↗
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Tubulin (CHEMBL2095182) ↗
Type PROTEIN COMPLEX GROUP
Organism Homo sapiens

Publication

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.
La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Sisinni L, Bolognesi A, Rensen WM, Miele A, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Brancale A, Novellino E, Dondio G, Vultaggio S, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R.
J Med Chem (2014) 57 : 6531 -6552
PubMed 25025991 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 5.65 6.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3318106 — — 1 6.07
CHEMBL3318112 — — 1 6.05
CHEMBL3318111 — — 1 6.02
CHEMBL3318091 — — 1 6.00
CHEMBL67 COMBRETASTATIN A4 -1.0 1 6.00
CHEMBL3318102 — — 1 6.00
CHEMBL3318115 — — 1 5.92
CHEMBL3318119 — — 1 5.92
CHEMBL3318105 — — 1 5.92
CHEMBL3318123 — — 1 5.89
CHEMBL3318122 — — 1 5.89
CHEMBL3318101 — — 1 5.89
CHEMBL3318095 — — 1 5.85
CHEMBL3318100 — — 1 5.85
CHEMBL3318104 — — 1 5.82
CHEMBL3318085 — — 1 5.82
CHEMBL3318125 — — 1 5.77
CHEMBL3318118 — — 1 5.77
CHEMBL3318114 — — 1 5.75
CHEMBL3318094 — — 1 5.68
CHEMBL3318124 — — 1 5.68
CHEMBL3318089 — — 1 5.66
CHEMBL3318090 — — 1 5.64
CHEMBL3318108 — — 1 5.60
CHEMBL3318092 — — 1 5.60
CHEMBL3318107 — — 1 5.60
CHEMBL3318103 — — 1 5.60
CHEMBL3318113 — — 1 5.57
CHEMBL107 COLCHICINE 4.0 1 5.50
CHEMBL3318116 — — 1 5.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3318106 — IC50 = 860.0 nM 6.07
CHEMBL3318112 — IC50 = 900.0 nM 6.05
CHEMBL3318111 — IC50 = 950.0 nM 6.02
CHEMBL3318091 — IC50 = 1000.0 nM 6.00
CHEMBL67 COMBRETASTATIN A4 IC50 = 1000.0 nM 6.00
CHEMBL3318102 — IC50 = 1000.0 nM 6.00
CHEMBL3318115 — IC50 = 1200.0 nM 5.92
CHEMBL3318119 — IC50 = 1200.0 nM 5.92
CHEMBL3318105 — IC50 = 1200.0 nM 5.92
CHEMBL3318101 — IC50 = 1300.0 nM 5.89
CHEMBL3318122 — IC50 = 1300.0 nM 5.89
CHEMBL3318123 — IC50 = 1300.0 nM 5.89
CHEMBL3318095 — IC50 = 1400.0 nM 5.85
CHEMBL3318100 — IC50 = 1400.0 nM 5.85
CHEMBL3318085 — IC50 = 1500.0 nM 5.82
CHEMBL3318104 — IC50 = 1500.0 nM 5.82
CHEMBL3318125 — IC50 = 1700.0 nM 5.77
CHEMBL3318118 — IC50 = 1700.0 nM 5.77
CHEMBL3318114 — IC50 = 1800.0 nM 5.75
CHEMBL3318124 — IC50 = 2100.0 nM 5.68
CHEMBL3318094 — IC50 = 2100.0 nM 5.68
CHEMBL3318089 — IC50 = 2200.0 nM 5.66
CHEMBL3318090 — IC50 = 2300.0 nM 5.64
CHEMBL3318108 — IC50 = 2500.0 nM 5.60
CHEMBL3318092 — IC50 = 2500.0 nM 5.60
CHEMBL3318107 — IC50 = 2500.0 nM 5.60
CHEMBL3318103 — IC50 = 2500.0 nM 5.60
CHEMBL3318113 — IC50 = 2700.0 nM 5.57
CHEMBL107 COLCHICINE IC50 = 3200.0 nM 5.50
CHEMBL3318116 — IC50 = 6100.0 nM 5.21
CHEMBL3318099 — IC50 = 6800.0 nM 5.17
CHEMBL3318088 — IC50 = 8800.0 nM 5.06
CHEMBL3318097 — IC50 = 8900.0 nM 5.05
CHEMBL3318110 — IC50 = 13000.0 nM 4.89
CHEMBL3318120 — IC50 = 15000.0 nM 4.82
CHEMBL3318131 — IC50 = 16000.0 nM 4.80
CHEMBL3318127 — IC50 > 40000.0 nM -
CHEMBL3318130 — IC50 > 40000.0 nM -
CHEMBL3318087 — IC50 > 40000.0 nM -
CHEMBL3318086 — IC50 > 40000.0 nM -