Assay Detail

CHEMBL3372685

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Functional

Cytotoxicity against paclitaxel-resistant human 1A9PTX22 cells

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Open DB target context

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	1A9/ptx-22
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Drug discovery targeting cell division proteins, microtubules and FtsZ.

Ojima I, Kumar K, Awasthi D, Vineberg JG.
Bioorg Med Chem (2014) 22 : 5060 -5077
PubMed 24680057 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	7.96	8.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL467163	—	—	1	8.68
CHEMBL450955	—	—	1	8.41
CHEMBL428647	PACLITAXEL	4.0	1	6.79

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL467163	—	IC50	=	2.1	nM	8.68
CHEMBL450955	—	IC50	=	3.88	nM	8.41
CHEMBL428647	PACLITAXEL	IC50	=	160.7	nM	6.79