Assay Detail
Functional
CHEMBL3372768
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Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production incubated for 24 hrs by Griess reagent based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Anti-inflammatory ursane- and oleanane-type triterpenoids from Vitex negundo var. cannabifolia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.56 | 4.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.78 |
| CHEMBL239077 | TOMENTIC ACID | — | 1 | 4.60 |
| CHEMBL3342057 | — | — | 1 | 4.58 |
| CHEMBL383749 | — | — | 1 | 4.56 |
| CHEMBL3342053 | — | — | 1 | 4.47 |
| CHEMBL3342058 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50 | QUERCETIN | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL239077 | TOMENTIC ACID | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL3342057 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL383749 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL3342053 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL3342058 | — | IC50 | = | 40500.0 | nM | 4.39 |