Assay Detail
Functional
CHEMBL3372826
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Inhibition of 6-OHDA-induced cell death in human SH-SY5Y cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.56 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355168 | — | — | 1 | 7.89 |
| CHEMBL3355181 | — | — | 1 | 6.55 |
| CHEMBL3355177 | — | — | 1 | 6.25 |
| CHEMBL3355165 | — | — | 1 | 5.53 |
| CHEMBL3355166 | — | — | 1 | - |
| CHEMBL3355174 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355168 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3355181 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL3355177 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL3355165 | — | IC50 | = | 2976.0 | nM | 5.53 |
| CHEMBL3355166 | — | IC50 | - | — | - | |
| CHEMBL3355174 | — | IC50 | - | — | - |