Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3372965

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against rat L6 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Exploring in vitro and in vivo Hsp90 inhibitors activity against human protozoan parasites.
Giannini G, Battistuzzi G.
Bioorg Med Chem Lett (2015) 25 : 462 -465
PubMed 25547934 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.35 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3234764 1 8.70
CHEMBL61 PODOFILOX 4.0 1 8.30
CHEMBL1941052 1 8.15
CHEMBL3353321 1 8.10
CHEMBL3234770 1 7.96
CHEMBL3353319 1 7.82
CHEMBL1941061 1 7.70
CHEMBL1941077 1 7.60
CHEMBL1940941 1 7.40
CHEMBL3233488 1 6.96
CHEMBL1941050 1 6.84
CHEMBL1941055 1 6.70
CHEMBL3353320 1 6.58
CHEMBL1941079 1 6.55
CHEMBL3233485 1 6.25
CHEMBL1940934 1 6.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3234764 IC50 = 2.0 nM 8.70
CHEMBL61 PODOFILOX IC50 = 5.0 nM 8.30
CHEMBL1941052 IC50 = 7.0 nM 8.15
CHEMBL3353321 IC50 = 8.0 nM 8.10
CHEMBL3234770 IC50 = 11.0 nM 7.96
CHEMBL3353319 IC50 = 15.0 nM 7.82
CHEMBL1941061 IC50 = 20.0 nM 7.70
CHEMBL1941077 IC50 = 25.0 nM 7.60
CHEMBL1940941 IC50 = 40.0 nM 7.40
CHEMBL3233488 IC50 = 110.0 nM 6.96
CHEMBL1941050 IC50 = 146.0 nM 6.84
CHEMBL1941055 IC50 = 201.0 nM 6.70
CHEMBL3353320 IC50 = 264.0 nM 6.58
CHEMBL1941079 IC50 = 279.0 nM 6.55
CHEMBL3233485 IC50 = 563.0 nM 6.25
CHEMBL1940934 IC50 = 888.0 nM 6.05