Assay Detail
Binding
CHEMBL3372984
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Inhibition of GST-tagged human Wee1
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 8.18 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355531 | — | — | 1 | 8.92 |
| CHEMBL3355528 | — | — | 1 | 8.80 |
| CHEMBL3355535 | — | — | 1 | 8.70 |
| CHEMBL3355518 | — | — | 1 | 8.64 |
| CHEMBL3355532 | — | — | 1 | 8.27 |
| CHEMBL3355522 | — | — | 1 | 8.26 |
| CHEMBL3355525 | — | — | 1 | 8.21 |
| CHEMBL3355524 | — | — | 1 | 8.18 |
| CHEMBL3355530 | — | — | 1 | 8.13 |
| CHEMBL3355523 | — | — | 1 | 8.08 |
| CHEMBL3355529 | — | — | 1 | 8.07 |
| CHEMBL3355519 | — | — | 1 | 7.68 |
| CHEMBL3355527 | — | — | 1 | 7.58 |
| CHEMBL3355521 | — | — | 1 | 7.06 |
| CHEMBL3355526 | — | — | 1 | - |
| CHEMBL3355533 | — | — | 1 | - |
| CHEMBL3355534 | — | — | 1 | - |
| CHEMBL3355520 | — | — | 1 | - |
| CHEMBL3355536 | — | — | 1 | - |
| CHEMBL3355537 | — | — | 1 | - |
| CHEMBL3355538 | — | — | 1 | - |
| CHEMBL3355539 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355531 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL3355528 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL3355535 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL3355518 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL3355532 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL3355522 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL3355525 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL3355524 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL3355530 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL3355523 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL3355529 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL3355519 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL3355527 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL3355521 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL3355526 | — | Ki | > | 3140.0 | nM | - |
| CHEMBL3355533 | — | Ki | < | 1.0 | nM | - |
| CHEMBL3355534 | — | Ki | < | 1.0 | nM | - |
| CHEMBL3355520 | — | Ki | > | 3140.0 | nM | - |
| CHEMBL3355536 | — | Ki | < | 1.0 | nM | - |
| CHEMBL3355537 | — | Ki | < | 1.0 | nM | - |
| CHEMBL3355538 | — | Ki | < | 1.0 | nM | - |
| CHEMBL3355539 | — | Ki | < | 1.0 | nM | - |