Assay Detail
Binding
CHEMBL3372999
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR (unknown origin) by Z'-Lyte kinase assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 6-(nitroimidazole-1H-alkyloxyl)-4-anilinoquinazolines as efficient EGFR inhibitors exerting cytotoxic effects both under normoxia and hypoxia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.74 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355877 | — | — | 1 | 9.49 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 9.35 |
| CHEMBL3355875 | — | — | 1 | 9.33 |
| CHEMBL3355881 | — | — | 1 | 9.31 |
| CHEMBL3355882 | — | — | 1 | 9.30 |
| CHEMBL3355876 | — | — | 1 | 9.29 |
| CHEMBL3355889 | — | — | 1 | 9.28 |
| CHEMBL3355880 | — | — | 1 | 9.25 |
| CHEMBL3355878 | — | — | 1 | 9.18 |
| CHEMBL3355874 | — | — | 1 | 9.05 |
| CHEMBL3355879 | — | — | 1 | 8.97 |
| CHEMBL3355890 | — | — | 1 | 8.93 |
| CHEMBL3355873 | — | — | 1 | 8.52 |
| CHEMBL3355888 | — | — | 1 | 8.46 |
| CHEMBL3355887 | — | — | 1 | 8.31 |
| CHEMBL3355886 | — | — | 1 | 7.82 |
| CHEMBL3355884 | — | — | 1 | 7.54 |
| CHEMBL3355883 | — | — | 1 | 7.42 |
| CHEMBL3355885 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355877 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL939 | GEFITINIB | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL3355875 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL3355881 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL3355882 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3355876 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL3355889 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL3355880 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL3355878 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL3355874 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL3355879 | — | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL3355890 | — | IC50 | = | 1.18 | nM | 8.93 |
| CHEMBL3355873 | — | IC50 | = | 3.05 | nM | 8.52 |
| CHEMBL3355888 | — | IC50 | = | 3.43 | nM | 8.46 |
| CHEMBL3355887 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3355886 | — | IC50 | = | 15.1 | nM | 7.82 |
| CHEMBL3355884 | — | IC50 | = | 28.5 | nM | 7.54 |
| CHEMBL3355883 | — | IC50 | = | 38.3 | nM | 7.42 |
| CHEMBL3355885 | — | IC50 | = | 51.2 | nM | 7.29 |