Assay Detail
Functional
CHEMBL3373093
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Cytotoxicity against human MCF7/R cells by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7R |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.86 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450955 | — | — | 1 | 9.48 |
| CHEMBL126916 | — | — | 1 | 8.68 |
| CHEMBL126932 | — | — | 1 | 8.55 |
| CHEMBL551337 | — | — | 1 | 8.37 |
| CHEMBL3334709 | — | — | 1 | 6.82 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.63 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.52 |
| CHEMBL1809080 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450955 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL126916 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL126932 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL551337 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3334709 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL1809080 | — | IC50 | - | — | - |