Assay Detail
Functional
CHEMBL3373099
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Cytotoxicity against human 1A9PTX10 cells by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1A9/ptx-10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.17 | 8.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126932 | — | — | 1 | 8.76 |
| CHEMBL3334709 | — | — | 1 | 8.62 |
| CHEMBL450955 | — | — | 1 | 8.54 |
| CHEMBL551337 | — | — | 1 | 8.28 |
| CHEMBL126916 | — | — | 1 | 7.97 |
| CHEMBL1809080 | — | — | 1 | 7.94 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126932 | — | IC50 | = | 1.75 | nM | 8.76 |
| CHEMBL3334709 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL450955 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL551337 | — | IC50 | = | 5.25 | nM | 8.28 |
| CHEMBL126916 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL1809080 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 81.4 | nM | 7.09 |