Assay Detail
Functional
CHEMBL3373101
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Cytotoxicity against human 1A9PTX22 cells by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1A9/ptx-22 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.14 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1809080 | — | — | 1 | 8.72 |
| CHEMBL450955 | — | — | 1 | 8.31 |
| CHEMBL126932 | — | — | 1 | 8.30 |
| CHEMBL551337 | — | — | 1 | 8.15 |
| CHEMBL126916 | — | — | 1 | 8.10 |
| CHEMBL3334709 | — | — | 1 | 7.92 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1809080 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL450955 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL126932 | — | IC50 | = | 4.95 | nM | 8.30 |
| CHEMBL551337 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL126916 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL3334709 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 32.8 | nM | 7.48 |