Assay Detail
Functional
CHEMBL3373103
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Cytotoxicity against human 1A9/A8 cells by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.31 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1809080 | — | — | 1 | 8.70 |
| CHEMBL3334709 | — | — | 1 | 8.42 |
| CHEMBL551337 | — | — | 1 | 8.40 |
| CHEMBL450955 | — | — | 1 | 8.40 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.38 |
| CHEMBL126932 | — | — | 1 | 7.94 |
| CHEMBL126916 | — | — | 1 | 7.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1809080 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3334709 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL551337 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL450955 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL126932 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL126916 | — | IC50 | = | 12.2 | nM | 7.91 |