Assay Detail
Binding
CHEMBL3373359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human NK3R expressed in CHO cells assessed as potentiation of senktide-induced effect
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel neurokinin 3 receptor (NK3R) selective agonists with resistance to proteolytic degradation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.83 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106124 | SENKTIDE | — | 1 | 7.96 |
| CHEMBL3361404 | — | — | 1 | 7.80 |
| CHEMBL3361408 | — | — | 1 | 7.00 |
| CHEMBL3361407 | — | — | 1 | 6.43 |
| CHEMBL3361405 | — | — | 1 | 6.04 |
| CHEMBL3361406 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106124 | SENKTIDE | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3361404 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3361408 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3361407 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL3361405 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL3361406 | — | EC50 | = | 1900.0 | nM | 5.72 |