Assay Detail
Functional
CHEMBL3373501
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Growth inhibition of human HeLa cells after 48 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.45 | 4.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480143 | — | — | 1 | 4.63 |
| CHEMBL3337769 | — | — | 1 | 4.26 |
| CHEMBL3337768 | — | — | 1 | - |
| CHEMBL3337770 | — | — | 1 | - |
| CHEMBL109 | VALPROIC ACID | 4.0 | 1 | - |
| CHEMBL3337771 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480143 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL3337769 | — | IC50 | = | 54400.0 | nM | 4.26 |
| CHEMBL3337768 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL3337770 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL109 | VALPROIC ACID | IC50 | = | 1000000.0 | nM | - |
| CHEMBL3337771 | — | IC50 | - | — | - |