Assay Detail
Binding
CHEMBL3373886
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DAGLalpha expressed in HEK293T cell membranes
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase α and α/β-hydrolase domain 6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.80 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3319620 | — | — | 1 | 7.75 |
| CHEMBL3319619 | — | — | 1 | 7.25 |
| CHEMBL3319622 | — | — | 1 | 7.19 |
| CHEMBL3319625 | — | — | 1 | 7.18 |
| CHEMBL3319623 | — | — | 1 | 7.04 |
| CHEMBL3319621 | — | — | 1 | 6.84 |
| CHEMBL3319618 | — | — | 1 | 6.73 |
| CHEMBL3319629 | — | — | 1 | 6.52 |
| CHEMBL3319637 | — | — | 1 | 6.29 |
| CHEMBL3319626 | — | — | 1 | 6.16 |
| CHEMBL3319624 | — | — | 1 | 5.80 |
| CHEMBL3319630 | — | — | 1 | - |
| CHEMBL3319628 | — | — | 1 | - |
| CHEMBL3319627 | — | — | 1 | - |
| CHEMBL3319631 | — | — | 1 | - |
| CHEMBL3319632 | — | — | 1 | - |
| CHEMBL3319633 | — | — | 1 | - |
| CHEMBL3319634 | — | — | 1 | - |
| CHEMBL3319635 | — | — | 1 | - |
| CHEMBL3319636 | — | — | 1 | - |
| CHEMBL3319638 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3319620 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3319619 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3319622 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3319625 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3319623 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3319621 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL3319618 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL3319629 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL3319637 | — | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL3319626 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL3319624 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3319630 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3319628 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3319627 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3319631 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3319632 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3319633 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3319634 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3319635 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3319636 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3319638 | — | IC50 | > | 10000.0 | nM | - |