Assay Detail
Binding
CHEMBL3373987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human prostate 5alpha-reductase type 2 assessed as conversion of [3H]testosterone to dihydrotestosterone
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Prostate gland |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (CHEMBL1856) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Effect of dehydroepiandrosterone derivatives on the activity of 5α-reductase isoenzymes and on cancer cell line PC-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.85 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3342891 | — | — | 1 | 8.49 |
| CHEMBL3342894 | — | — | 1 | 8.10 |
| CHEMBL710 | FINASTERIDE | 4.0 | 1 | 8.07 |
| CHEMBL3342892 | — | — | 1 | 7.89 |
| CHEMBL3342895 | — | — | 1 | 7.82 |
| CHEMBL3342896 | — | — | 1 | 7.30 |
| CHEMBL3342893 | — | — | 1 | 7.30 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | - |
| CHEMBL3342906 | — | — | 1 | - |
| CHEMBL3342905 | — | — | 1 | - |
| CHEMBL3342904 | — | — | 1 | - |
| CHEMBL3342903 | — | — | 1 | - |
| CHEMBL3342902 | — | — | 1 | - |
| CHEMBL3342901 | — | — | 1 | - |
| CHEMBL3342900 | — | — | 1 | - |
| CHEMBL3342899 | — | — | 1 | - |
| CHEMBL3342898 | — | — | 1 | - |
| CHEMBL3342897 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3342891 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3342894 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL710 | FINASTERIDE | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL3342892 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3342895 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3342896 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3342893 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | - | — | - | |
| CHEMBL3342906 | — | IC50 | - | — | - | |
| CHEMBL3342905 | — | IC50 | - | — | - | |
| CHEMBL3342904 | — | IC50 | - | — | - | |
| CHEMBL3342903 | — | IC50 | - | — | - | |
| CHEMBL3342902 | — | IC50 | - | — | - | |
| CHEMBL3342901 | — | IC50 | - | — | - | |
| CHEMBL3342900 | — | IC50 | - | — | - | |
| CHEMBL3342899 | — | IC50 | - | — | - | |
| CHEMBL3342898 | — | IC50 | - | — | - | |
| CHEMBL3342897 | — | IC50 | - | — | - |