Assay Detail
Binding
CHEMBL3374136
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Inhibition of PDE4B (unknown origin)
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4B (CHEMBL275) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and SAR study of 2-(4-pyridylamino)thieno[3,2-d]pyrimidin-4(3H)-ones as soluble and highly potent PDE7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.04 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360172 | — | — | 1 | 7.70 |
| CHEMBL3360167 | — | — | 1 | 7.25 |
| CHEMBL3360171 | — | — | 1 | 6.75 |
| CHEMBL3360168 | — | — | 1 | 6.75 |
| CHEMBL3360170 | — | — | 1 | 6.55 |
| CHEMBL3360169 | — | — | 1 | 6.51 |
| CHEMBL3360166 | — | — | 1 | 6.21 |
| CHEMBL3360165 | — | — | 1 | 6.17 |
| CHEMBL3360160 | — | — | 1 | 5.57 |
| CHEMBL3360161 | — | — | 1 | 5.52 |
| CHEMBL3360155 | — | — | 1 | 5.37 |
| CHEMBL3354160 | — | — | 1 | 5.31 |
| CHEMBL3360164 | — | — | 1 | 5.28 |
| CHEMBL3360154 | — | — | 1 | 5.13 |
| CHEMBL3360163 | — | — | 1 | 4.52 |
| CHEMBL3360162 | — | — | 1 | - |
| CHEMBL3360159 | — | — | 1 | - |
| CHEMBL3360158 | — | — | 1 | - |
| CHEMBL3360157 | — | — | 1 | - |
| CHEMBL3360156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360172 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3360167 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3360171 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3360168 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3360170 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3360169 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3360166 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3360165 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3360160 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3360161 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3360155 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3354160 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL3360164 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL3360154 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3360163 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3360162 | — | IC50 | - | — | - | |
| CHEMBL3360159 | — | IC50 | - | — | - | |
| CHEMBL3360158 | — | IC50 | - | — | - | |
| CHEMBL3360157 | — | IC50 | - | — | - | |
| CHEMBL3360156 | — | IC50 | - | — | - |