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Assay Detail

CHEMBL3374430

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Functional
Cytotoxicity against human KG1 cells after 48 hrs by Alamar blue assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KG-1
Confidence 1 — Organism
Curated By Autocuration

Publication

Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines.
Cardoso MF, Rodrigues PC, Oliveira ME, Gama IL, da Silva IM, Santos IO, Rocha DR, Pinho RT, Ferreira VF, de Souza MC, da Silva Fde C, Silva-Jr FP.
Eur J Med Chem (2014) 84 : 708 -717
PubMed 25064348 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.16 5.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3317591 1 5.88
CHEMBL3317586 1 5.81
CHEMBL454935 1 5.70
CHEMBL3317587 1 5.42
CHEMBL3317585 1 5.41
CHEMBL453114 1 5.31
CHEMBL511104 1 5.27
CHEMBL507556 1 5.25
CHEMBL3317590 1 5.25
CHEMBL3317589 1 5.25
CHEMBL509219 1 5.22
CHEMBL3317584 1 5.12
CHEMBL3317583 1 5.08
CHEMBL3317592 1 5.02
CHEMBL3317594 1 4.96
CHEMBL3317593 1 4.91
CHEMBL454129 1 4.89
CHEMBL394882 NOR-BETA-LAPACHONE 1 4.76
CHEMBL3317588 1 4.52
CHEMBL2023280 1 4.12
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3317591 IC50 = 1320.0 nM 5.88
CHEMBL3317586 IC50 = 1550.0 nM 5.81
CHEMBL454935 IC50 = 2000.0 nM 5.70
CHEMBL3317587 IC50 = 3790.0 nM 5.42
CHEMBL3317585 IC50 = 3920.0 nM 5.41
CHEMBL453114 IC50 = 4920.0 nM 5.31
CHEMBL511104 IC50 = 5330.0 nM 5.27
CHEMBL507556 IC50 = 5630.0 nM 5.25
CHEMBL3317590 IC50 = 5630.0 nM 5.25
CHEMBL3317589 IC50 = 5580.0 nM 5.25
CHEMBL509219 IC50 = 6060.0 nM 5.22
CHEMBL3317584 IC50 = 7620.0 nM 5.12
CHEMBL3317583 IC50 = 8410.0 nM 5.08
CHEMBL3317592 IC50 = 9580.0 nM 5.02
CHEMBL3317594 IC50 = 11070.0 nM 4.96
CHEMBL3317593 IC50 = 12270.0 nM 4.91
CHEMBL454129 IC50 = 12800.0 nM 4.89
CHEMBL394882 NOR-BETA-LAPACHONE IC50 = 17200.0 nM 4.76
CHEMBL3317588 IC50 = 30000.0 nM 4.52
CHEMBL2023280 IC50 = 76200.0 nM 4.12
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE IC50 - -