Assay Detail

CHEMBL3374652

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Functional

Antiinvasive activity against human Gli4 cells after 48 hrs by matrigel assay

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Open DB target context

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NON-PROTEIN TARGET (CHEMBL3879801) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	Gli4
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

C-glycoside mimetics inhibit glioma stem cell proliferation, migration, and invasion.

Clarion L, Jacquard C, Sainte-Catherine O, Decoux M, Loiseau S, Rolland M, Lecouvey M, Hugnot JP, Volle JN, Virieux D, Pirat JL, Bakalara N.
J Med Chem (2014) 57 : 8293 -8306
PubMed 25211466 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	6.54	6.54

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3341777	—	—	1	6.54

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3341777	—	Ki	=	290.0	nM	6.54