Assay Detail
Binding
CHEMBL3374860
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.99 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355542 | — | — | 1 | 8.30 |
| CHEMBL1952329 | SGI-1776 | 1.0 | 1 | 8.12 |
| CHEMBL3355552 | — | — | 1 | 7.77 |
| CHEMBL3355987 | — | — | 1 | 7.64 |
| CHEMBL3355557 | — | — | 1 | 7.62 |
| CHEMBL3355550 | — | — | 1 | 7.60 |
| CHEMBL3355544 | — | — | 1 | 7.57 |
| CHEMBL3355541 | — | — | 1 | 7.35 |
| CHEMBL3355551 | — | — | 1 | 7.27 |
| CHEMBL3355553 | — | — | 1 | 7.18 |
| CHEMBL3355988 | — | — | 1 | 7.17 |
| CHEMBL3355558 | — | — | 1 | 7.03 |
| CHEMBL3355555 | — | — | 1 | 6.96 |
| CHEMBL3355543 | — | — | 1 | 6.88 |
| CHEMBL3355554 | — | — | 1 | 6.83 |
| CHEMBL3355549 | — | — | 1 | 6.83 |
| CHEMBL3355990 | — | — | 1 | 6.79 |
| CHEMBL3355991 | — | — | 1 | 6.78 |
| CHEMBL3355989 | — | — | 1 | 6.73 |
| CHEMBL3355545 | — | — | 1 | 6.71 |
| CHEMBL3355546 | — | — | 1 | 6.69 |
| CHEMBL3355559 | — | — | 1 | 6.62 |
| CHEMBL3355547 | — | — | 1 | 6.42 |
| CHEMBL3355560 | — | — | 1 | 6.42 |
| CHEMBL3355548 | — | — | 1 | 6.20 |
| CHEMBL3355540 | — | — | 1 | 4.28 |
| CHEMBL3355556 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355542 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1952329 | SGI-1776 | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL3355552 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3355987 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3355557 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3355550 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3355544 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3355541 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL3355551 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3355553 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3355988 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3355558 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3355555 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL3355543 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL3355554 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL3355549 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL3355990 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL3355991 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL3355989 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL3355545 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL3355546 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL3355559 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL3355547 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL3355560 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL3355548 | — | IC50 | = | 633.0 | nM | 6.20 |
| CHEMBL3355540 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL3355556 | — | IC50 | - | — | - |