Compound Detail
CHEMBL3355989
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Basic Information
| ChEMBL ID | CHEMBL3355989 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SWFAGSRXXWSCDS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
342.8
MW (Da)
3.89
ALogP
5
HBA
1
HBD
51.5
PSA (Ų)
0.78
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.73
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 6.73 | 6.73 | 186.0 | 1 |
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | IC50 | 5.79 | 5.79 | 1640.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | IC50 | = | 186.0 | nM | 6.73 | Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detecti... | 25589932 |
| Serine/threonine-protein kinase pim-2 | IC50 | = | 1640.0 | nM | 5.79 | Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detecti... | 25589932 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 25589932 | 10.1021/ml500300c | Serine/threonine-protein kinase pim-1 | 1 |
| 25589932 | 10.1021/ml500300c | Serine/threonine-protein kinase pim-2 | 1 |
Data from ChEMBL 36 via Core Engine