Assay Detail
Binding
CHEMBL3374865
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rodent selectivity of piperidine-4-yl-1H-indoles, a series of CC chemokine receptor-3 (CCR3) antagonists: insights from a receptor model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.31 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355965 | — | — | 1 | 8.40 |
| CHEMBL3355940 | — | — | 1 | 8.37 |
| CHEMBL3355954 | — | — | 1 | 8.33 |
| CHEMBL3355944 | — | — | 1 | 8.32 |
| CHEMBL3355953 | — | — | 1 | 8.31 |
| CHEMBL3355962 | — | — | 1 | 8.30 |
| CHEMBL3355960 | — | — | 1 | 8.30 |
| CHEMBL3355932 | — | — | 1 | 8.24 |
| CHEMBL3355964 | — | — | 1 | 7.96 |
| CHEMBL3355956 | — | — | 1 | 7.80 |
| CHEMBL3355942 | — | — | 1 | 7.51 |
| CHEMBL3355934 | — | — | 1 | 7.50 |
| CHEMBL3355938 | — | — | 1 | 7.48 |
| CHEMBL3355966 | — | — | 1 | 7.47 |
| CHEMBL3355950 | — | — | 1 | 7.42 |
| CHEMBL3355945 | — | — | 1 | 7.34 |
| CHEMBL3355959 | — | — | 1 | 7.27 |
| CHEMBL3355933 | — | — | 1 | 7.22 |
| CHEMBL3355961 | — | — | 1 | 7.22 |
| CHEMBL3355952 | — | — | 1 | 7.21 |
| CHEMBL3355943 | — | — | 1 | 7.18 |
| CHEMBL3355951 | — | — | 1 | 7.17 |
| CHEMBL3355935 | — | — | 1 | 7.11 |
| CHEMBL3355957 | — | — | 1 | 7.09 |
| CHEMBL3355946 | — | — | 1 | 7.07 |
| CHEMBL3355936 | — | — | 1 | 7.02 |
| CHEMBL3355963 | — | — | 1 | 7.01 |
| CHEMBL3355939 | — | — | 1 | 7.00 |
| CHEMBL3355958 | — | — | 1 | 6.92 |
| CHEMBL3355947 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355965 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL3355940 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL3355954 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL3355944 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL3355953 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL3355962 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL3355960 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL3355932 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL3355964 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3355956 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3355942 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL3355934 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL3355938 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL3355966 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL3355950 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL3355945 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL3355959 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL3355933 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL3355961 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL3355952 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL3355943 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL3355951 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL3355935 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL3355957 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL3355946 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL3355936 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL3355963 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL3355939 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL3355958 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3355947 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL3355948 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL3355937 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL3355941 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL3355949 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL3355955 | — | Ki | = | 6900.0 | nM | 5.16 |