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Assay Detail

CHEMBL3375012

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO/T
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Substance-K receptor (CHEMBL2327)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Toward fluorescent probes for G-protein-coupled receptors (GPCRs).
Ma Z, Du L, Li M.
J Med Chem (2014) 57 : 8187 -8203
PubMed 24983484 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 9 8.45 9.81

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2370064 1 9.81
CHEMBL217406 NEUROKININ A 1 8.92
CHEMBL3360196 1 8.87
CHEMBL3360197 1 8.84
CHEMBL3360198 1 8.83
CHEMBL3360199 1 8.80
CHEMBL3360201 1 8.23
CHEMBL3360200 1 8.08
CHEMBL3360202 1 5.71

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2370064 Ki = 0.1549 nM 9.81
CHEMBL217406 NEUROKININ A Ki = 1.202 nM 8.92
CHEMBL3360196 Ki = 1.349 nM 8.87
CHEMBL3360197 Ki = 1.445 nM 8.84
CHEMBL3360198 Ki = 1.479 nM 8.83
CHEMBL3360199 Ki = 1.585 nM 8.80
CHEMBL3360201 Ki = 5.888 nM 8.23
CHEMBL3360200 Ki = 8.318 nM 8.08
CHEMBL3360202 Ki = 1949.84 nM 5.71