Assay Detail
Binding
CHEMBL3375172
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Staphylococcus aureus recombinant HPPK by surface plasmon resonance analysis in presence of ATP
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
2-amino-4-hydroxy-6-hydroxymethyldihydropteridin e pyrophosphokinase (CHEMBL3559681) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 5.73 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3359162 | — | — | 1 | 6.35 |
| CHEMBL3233202 | — | — | 1 | 6.18 |
| CHEMBL3359158 | — | — | 1 | 6.09 |
| CHEMBL3233207 | — | — | 1 | 5.96 |
| CHEMBL3233201 | — | — | 1 | 5.85 |
| CHEMBL3359161 | — | — | 1 | 5.75 |
| CHEMBL3359160 | — | — | 1 | 5.73 |
| CHEMBL3233212 | — | — | 1 | 5.72 |
| CHEMBL3233211 | — | — | 1 | 5.55 |
| CHEMBL3359163 | — | — | 1 | 5.55 |
| CHEMBL3359159 | — | — | 1 | 5.11 |
| CHEMBL178006 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3359162 | — | Kd | = | 450.0 | nM | 6.35 |
| CHEMBL3233202 | — | Kd | = | 660.0 | nM | 6.18 |
| CHEMBL3359158 | — | Kd | = | 810.0 | nM | 6.09 |
| CHEMBL3233207 | — | Kd | = | 1090.0 | nM | 5.96 |
| CHEMBL3233201 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL3359161 | — | Kd | = | 1790.0 | nM | 5.75 |
| CHEMBL3359160 | — | Kd | = | 1850.0 | nM | 5.73 |
| CHEMBL3233212 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL3233211 | — | Kd | = | 2800.0 | nM | 5.55 |
| CHEMBL3359163 | — | Kd | = | 2810.0 | nM | 5.55 |
| CHEMBL3359159 | — | Kd | = | 7800.0 | nM | 5.11 |
| CHEMBL178006 | — | Kd | = | 12600.0 | nM | 4.90 |