Assay Detail
Binding
CHEMBL3375174
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Binding affinity to Escherichia coli DHPS by surface plasmon resonance analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 5.02 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3233211 | — | — | 1 | 5.80 |
| CHEMBL3233207 | — | — | 1 | 5.41 |
| CHEMBL3233201 | — | — | 1 | 5.41 |
| CHEMBL3359160 | — | — | 1 | 5.11 |
| CHEMBL3233212 | — | — | 1 | 5.09 |
| CHEMBL3359158 | — | — | 1 | 5.08 |
| CHEMBL3359162 | — | — | 1 | 5.07 |
| CHEMBL3359163 | — | — | 1 | 5.01 |
| CHEMBL3233202 | — | — | 1 | 4.91 |
| CHEMBL3359159 | — | — | 1 | 4.85 |
| CHEMBL3359161 | — | — | 1 | 4.36 |
| CHEMBL178006 | — | — | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3233211 | — | Kd | = | 1600.0 | nM | 5.80 |
| CHEMBL3233207 | — | Kd | = | 3900.0 | nM | 5.41 |
| CHEMBL3233201 | — | Kd | = | 3900.0 | nM | 5.41 |
| CHEMBL3359160 | — | Kd | = | 7800.0 | nM | 5.11 |
| CHEMBL3233212 | — | Kd | = | 8200.0 | nM | 5.09 |
| CHEMBL3359158 | — | Kd | = | 8400.0 | nM | 5.08 |
| CHEMBL3359162 | — | Kd | = | 8500.0 | nM | 5.07 |
| CHEMBL3359163 | — | Kd | = | 9740.0 | nM | 5.01 |
| CHEMBL3233202 | — | Kd | = | 12300.0 | nM | 4.91 |
| CHEMBL3359159 | — | Kd | = | 14200.0 | nM | 4.85 |
| CHEMBL3359161 | — | Kd | = | 43900.0 | nM | 4.36 |
| CHEMBL178006 | — | Kd | = | 76200.0 | nM | 4.12 |