Assay Detail
Binding
CHEMBL3375186
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human carbonic anhydrase 1 at pH7 and 37 degC by fluorescent thermal shift assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.19 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2333416 | — | — | 1 | 9.96 |
| CHEMBL2333417 | — | — | 1 | 9.70 |
| CHEMBL3359181 | — | — | 1 | 6.15 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 5.85 |
| CHEMBL3359179 | — | — | 1 | 4.30 |
| CHEMBL3359180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2333416 | — | Kd | = | 0.11 | nM | 9.96 |
| CHEMBL2333417 | — | Kd | = | 0.2 | nM | 9.70 |
| CHEMBL3359181 | — | Kd | = | 710.0 | nM | 6.15 |
| CHEMBL20 | ACETAZOLAMIDE | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL3359179 | — | Kd | = | 50000.0 | nM | 4.30 |
| CHEMBL3359180 | — | Kd | > | 200000.0 | nM | - |