Assay Detail
Binding
CHEMBL3375276
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reactivation of sarin-inhibited human acetylcholinesterase assessed as dissociation constant
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New efficient imidazolium aldoxime reactivators for nerve agent-inhibited acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 4.13 | 4.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360487 | — | — | 1 | 4.39 |
| CHEMBL2181432 | — | — | 1 | 4.06 |
| CHEMBL291233 | OBIDOXIME CHLORIDE | 2.0 | 1 | 4.05 |
| CHEMBL385181 | HI-6 | — | 1 | 4.03 |
| CHEMBL32778 | TRIMEDOXIME | 2.0 | 1 | - |
| CHEMBL3360486 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360487 | — | Kd | = | 41000.0 | nM | 4.39 |
| CHEMBL2181432 | — | Kd | = | 88000.0 | nM | 4.06 |
| CHEMBL291233 | OBIDOXIME CHLORIDE | Kd | = | 90000.0 | nM | 4.05 |
| CHEMBL385181 | HI-6 | Kd | = | 93000.0 | nM | 4.03 |
| CHEMBL32778 | TRIMEDOXIME | Kd | - | — | - | |
| CHEMBL3360486 | — | Kd | = | 143000.0 | nM | - |